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Bronchiolitis obliterans results in worsening shortness of breath, wheezing, and a dry cough.The symptoms can start gradually, or severe symptoms can occur suddenly. [9] [10] These symptoms represent an obstructive pattern that is non-reversible with bronchodilator therapy, and need to be related to various lung insults. [11]
When a substance other than air fills an area of the lung it increases that area's density. On both x-ray and CT, this appears more grey or hazy as opposed to the normally dark-appearing lungs. Although it can sometimes be seen in normal lungs, common pathologic causes include infections, interstitial lung disease, and pulmonary edema. [2] [3]
Where present it is a strong diagnostic factor of ABPA and distinguishes symptoms from other causes of bronchiectasis. [11] CT scans may more rarely reveal mosaic-appearance attenuation, centrilobular lung nodules, tree-in-bud opacities, and pleuropulmonary fibrosis (a finding consistent with CPA, a disease with ABPA as a known precursor). [1]
Globally, tuberculosis is likely the most common infectious cause of lung cavities. [6] Less commonly, parasitic infections can cause cavities. [5] Viral infections almost never cause lung cavities; in a small study of immunocompromised patients with a lung infection, the presence of a cavity on CT scan essentially ruled out viral infection.
The pathophysiology of type 3 respiratory failure often includes lung atelectasis, which is a term used to describe a collapsing of the functional units of the lung that allow for gas exchange. Because atelectasis occurs so commonly in the perioperative period, this form is also called perioperative respiratory failure.
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The differential diagnosis includes other types of lung disease that cause similar symptoms and show similar abnormalities on chest radiographs. Some of these diseases cause fibrosis, scarring or honeycomb change. The most common considerations include: chronic hypersensitivity pneumonitis; non-specific interstitial pneumonia; sarcoidosis
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