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Targeted delivery is believed to improve efficacy while reducing side-effects. When implementing a targeted release system, the following design criteria for the system must be taken into account: the drug properties, side-effects of the drugs, the route taken for the delivery of the drug, the targeted site, and the disease.
Gradient responsive drug delivery systems are stimulated to deliver therapeutics through contact with an endogenous chemical gradient. When the system comes into contact with its specific chemical gradient, increased concentration of the chemical can lead to the conformational change or degradation of a drug carrier to allow drug release.
Modified-release dosage is a mechanism that (in contrast to immediate-release dosage) delivers a drug with a delay after its administration (delayed-release dosage) or for a prolonged period of time (extended-release [ER, XR, XL] dosage) or to a specific target in the body (targeted-release dosage). [1]
Interest in targeted drug delivery has grown drastically due to its potential implications in the treatment of cancers and other chronic diseases. [23] [24] [25] In order to achieve efficient targeted delivery, the designed system must avoid the host's defense mechanisms and circulate to its intended site of action. [26]
Nanoparticle drug delivery systems are engineered technologies that use nanoparticles for the targeted delivery and controlled release of therapeutic agents. The modern form of a drug delivery system should minimize side-effects and reduce both dosage and dosage frequency. Recently, nanoparticles have aroused attention due to their potential ...
The purpose of the pH- triggered drug release is to deliver the drug precisely to the area of the tumor and not activate and release the drug in healthy tissue. [1] The complex compromises a drug delivery unit made up of a carrier molecule made up of organic nanomaterials, inorganic nanomaterials, composite nanomaterials, and anti-tumor drugs.
Targeted therapy or molecularly targeted therapy is one of the major modalities of medical treatment (pharmacotherapy) for cancer, [1] others being hormonal therapy and cytotoxic chemotherapy.
The bottom probe demonstrates the use of ultrasound for therapeutic benefits, which often utilize high-energy, focused ultrasound beams. In the above applications, the ultrasound passes through human tissue where it is the main source of the observed biological effect (the oscillation of abrasive dental tools at ultrasonic frequencies therefore ...