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  2. Carbamazepine - Wikipedia

    en.wikipedia.org/wiki/Carbamazepine

    The plasma half-life is about 35 to 40 hours when carbamazepine is given as single dose, but it is a strong inducer of liver enzymes, and the plasma half-life shortens to about 12 to 17 hours when it is given repeatedly. The half-life can be further shortened to 9–10 hours by other enzyme inducers such as phenytoin or phenobarbital. About 70% ...

  3. List of benzodiazepines - Wikipedia

    en.wikipedia.org/wiki/List_of_benzodiazepines

    Low IC 50 or high pIC 50 values indicate tighter binding (pIC 50 of 8.0 = IC 50 of 10nM, pIC 50 of 9.0 = IC 50 of 1nM, etc.) These are non subtype selective IC 50 values averaged across all GABA A receptor subtypes , so subtype selective compounds with strong binding at one subtype but weak at others will appear unusually weak due to averaging ...

  4. List of antidepressants - Wikipedia

    en.wikipedia.org/wiki/List_of_antidepressants

    Esketamine (Spravato) – non-competitive NMDA receptor antagonist, other actions [13] Gepirone (Exxua) – 5-HT 1A receptor partial agonist and α 2-adrenergic receptor antagonist; Opipramol (Insidon) — σ 1 receptor agonist, other actions; Tianeptine (Stablon, Coaxil, Tianeurax) – weak and atypical μ-opioid receptor agonist, other actions

  5. Cenobamate - Wikipedia

    en.wikipedia.org/wiki/Cenobamate

    In the United States, cenobamate is indicated for the treatment of partial-onset seizures in adults. [3]In the European Union, it is indicated for the adjunctive treatment of focal-onset seizures with or without secondary generalization in adults with epilepsy who have not been adequately controlled despite a history of treatment with at least two anti-epileptic medications.

  6. CYP3A4 - Wikipedia

    en.wikipedia.org/wiki/CYP3A4

    CYP3A4 increases to approximately 40% of adult levels in the fourth month of life and 72% at 12 months. [13] [14] Although CYP3A4 is predominantly found in the liver, it is also present in other organs and tissues of the body, where it may play an important role in metabolism. CP3A4 is the major CYP enzyme in the intestine. [15]

  7. Clonazepam - Wikipedia

    en.wikipedia.org/wiki/Clonazepam

    It has an elimination half-life of 19–60 hours. [10] Peak blood concentrations of 6.5–13.5 ng/mL were usually reached within 1–2 hours following a single 2 mg oral dose of micronized clonazepam in healthy adults. In some individuals, however, peak blood concentrations were reached at 4–8 hours. [131]

  8. Clozapine - Wikipedia

    en.wikipedia.org/wiki/Clozapine

    Clozapine, sold under the brand name Clozaril among others, is a psychiatric medication and was the first atypical antipsychotic to be discovered. [6] It is primarily used to treat people with schizophrenia and schizoaffective disorder who have had an inadequate response to two other antipsychotics, or who have been unable to tolerate other drugs due to extrapyramidal side effects.

  9. Lamotrigine - Wikipedia

    en.wikipedia.org/wiki/Lamotrigine

    Lamotrigine is a phenyltriazine, [5] making it chemically different from other anticonvulsants. [8] Its mechanism of action is not clear, but it appears to inhibit release of excitatory neurotransmitters via voltage-sensitive sodium channels and voltage-gated calcium channels in neurons. [8] [10] [11]

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