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Chronic recurrent multifocal osteomyelitis (CRMO) is a rare condition (1:1,000,000), in which the bones have lesions, inflammation, and pain. It is called multifocal because it can appear in different parts of the body, primarily bones, and osteomyelitis because it is very similar to that disease, although CRMO appears to be without any infection .
Long bones (30% of patients): [citation needed] usually metadiaphyseal and located in the distal femur and proximal tibia. It looks like chronic osteomyelitis but will not have a sequestrum or abscess. Flat bones (10% of patients): [citation needed] mandible and ilium. Peripheral arthritis has been reported in 92% of cases of SAPHO as well.
Chronic obstructive pulmonary disease: No consistent evidence of association with autoimmunity. [122] [123] Chronic recurrent multifocal osteomyelitis: LPIN2, D18S60. Synonyms: Majeed syndrome. Complement component 2 deficiency: Possibly symptomatic of autoimmune diseases, but not a disease. Congenital heart block
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Osteomyelitis is a secondary complication in 1–3% of patients with pulmonary tuberculosis. [13] In this case, the bacteria, in general, spread to the bone through the circulatory system , first infecting the synovium (due to its higher oxygen concentration) before spreading to the adjacent bone. [ 13 ]
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Majeed syndrome is an inherited skin disorder characterized by chronic recurrent multifocal osteomyelitis, congenital dyserythropoietic anemia and a neutrophilic dermatosis. [1] It is classified as an autoinflammatory bone disorder. The condition is found in people with two defective copies (autosomal recessive inheritance) of the LPIN2 gene.