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The signs and symptoms of hypopituitarism vary, depending on which hormones are undersecreted and on the underlying cause of the abnormality. The diagnosis of hypopituitarism is made by blood tests, but often specific scans and other investigations are needed to find the underlying cause, such as tumors of the pituitary, and the ideal treatment ...
However, clinical, laboratory data, and imaging can all help with the diagnosis.[8] First and foremost, patients present with symptoms of hypopituitarism and must undergo pituitary hormone function evaluation. [1] Biopsy is the only means of accurate diagnosis as no autoantigen has been discovered.
Most pediatric endocrinologists monitor growth and adjust dose every 3–6 months and many of these visits involve blood tests and x-rays. Treatment is usually extended as long as the child is growing, and lifelong continuation may be recommended for those most severely deficient.
Hypophysitis, inflammation of the pituitary gland.; Autoimmune hypophysitis (or lymphocytic hypophysitis), inflammation of the pituitary gland due to autoimmunity.; Nelson's syndrome, may occur after surgical removal of both adrenal glands, an out-dated method of treating Cushing's disease.
It is a known side-effect of the new immune checkpoint inhibitors of the CTLA-4 inhibitor and PD-L1 inhibitor classes, used for the treatment of melanoma, and should be considered in patients on these drugs who present with endocrine dysfunction. [citation needed]
PSIS is a common cause of congenital hypopituitarism, and causes a permanent growth hormone deficit. Some PSIS-affected individuals may also present with adrenal hypoplasia (5–29%), diabetes insipidus (5–29%), primary amenorrhea (5–29%), hypothyroidism (30–79%), failure to thrive (80–99%), septooptic dysplasia (5–29%), and Fanconi ...
Most protocols require patients to visit the treatment center daily for up to several weeks to complete treatment. Patients are also recommended to take hormone therapy for up to five years, which ...
Sheehan's syndrome, also known as postpartum pituitary gland necrosis, occurs when the pituitary gland is damaged due to significant blood loss and hypovolemic shock (ischemic necrosis) or stroke, originally described during or after childbirth leading to decreased functioning of the pituitary gland (hypopituitarism). [1]