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Protamine insulin was first created in 1936 and NPH insulin in 1946. [1] It is on the World Health Organization's List of Essential Medicines. [4] NPH is an abbreviation for "neutral protamine Hagedorn". [1] In 2020, insulin isophane was the 221st most commonly prescribed medication in the United States, with more than 2 million prescriptions.
Giving insulin with an insulin pen. Insulin pump in use. Insulin is used to treat a number of diseases including diabetes and its acute complications such as diabetic ketoacidosis and hyperosmolar hyperglycemic states. It is also used along with glucose to treat high blood potassium levels. Use during pregnancy is relatively safe for the baby. [6]
Novolin is the brand name of three distinct insulin-containing products [1] manufactured by Novo Nordisk: [2] Novolin 70/30, an insulin preparation containing mixed NPH and regular insulin, respectively; Novolin N, an insulin preparation containing NPH insulin; Novolin R, an insulin preparation containing regular insulin
Regular insulin, also known as neutral insulin and soluble insulin, is a type of short-acting medical insulin. [2] It is used to treat type 1 diabetes , type 2 diabetes , gestational diabetes , and complications of diabetes such as diabetic ketoacidosis and hyperosmolar hyperglycemic states . [ 5 ]
Mylan also makes the distinction that this isn’t the Semglee brand pen, but unbranded Insulin Glargine-yfgn pens. This covers batch No. BF21002895, expiration August 2023.
Hagedorn discovered that the addition of protamine to insulin caused the insulin to form microscopic clumps. These clumps took longer to dissolve into the bloodstream. This complex of protamine and insulin is known as NPH (neutral protamine Hagedorn) insulin. It is one of the earliest example of engineering drug delivery.
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