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Brimonidine/timolol, sold under the brand name Combigan among others, is a fixed-dose combination medication eye drop used for the treatment of glaucoma. [1] It is a combination of brimonidine (an α 2 adrenergic agonist ) and timolol (a β adrenergic blocker ).
Brimonidine is an α 2 adrenergic agonist. [4]Peripheral α 2 agonist activity results in vasoconstriction of blood vessels (as opposed to central α 2 agonist activity that decreases sympathetic tone, as can be seen by the medication clonidine).
Allergan plc is an American, Irish-domiciled pharmaceutical company that acquires, develops, manufactures and markets brand name drugs and medical devices in the areas of medical aesthetics, eye care, central nervous system, and gastroenterology.
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The company produces and sells a variety of medicines, with 1,400 approved therapeutic molecules in its portfolio. [26] It owns brands (like Viagra , Xanax , Lipitor ), [ 6 ] [ 27 ] generics , including branded and complex generics, biosimilars , [ 28 ] [ 29 ] and over-the-counter (OTC) drugs and active pharmaceutical ingredients .
Li T, Lindsley K, Rouse B, Hong H, Shi Q, Friedman DS, et al. (January 2016). "Comparative Effectiveness of First-Line Medications for Primary Open-Angle Glaucoma: A Systematic Review and Network Meta-analysis".
The expansion of the company – from a family business to a company designing, developing and marketing hundreds of healthcare and home environment products worldwide – came through research and development, acquisitions and licensing agreements. [4] For more than 80 years, members of the Katzman family owned and managed Kaz.
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