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  2. Long-term impact of alcohol on the brain - Wikipedia

    en.wikipedia.org/wiki/Long-term_impact_of...

    The long-term impact of alcohol on the brain has become a growing area of research focus. While researchers have found that moderate alcohol consumption in older adults is associated with better cognition and well-being than abstinence, [1] excessive alcohol consumption is associated with widespread and significant brain lesions.

  3. Dopamine - Wikipedia

    en.wikipedia.org/wiki/Dopamine

    TAAR1 is a high-affinity receptor for dopamine, trace amines, and certain substituted amphetamines that is located along membranes in the intracellular milieu of the presynaptic cell; [33] activation of the receptor can regulate dopamine signaling by inducing dopamine reuptake inhibition and efflux as well as by inhibiting neuronal firing ...

  4. Dopamine receptor - Wikipedia

    en.wikipedia.org/wiki/Dopamine_receptor

    Dopamine. Dopamine receptors are a class of G protein-coupled receptors that are prominent in the vertebrate central nervous system (CNS). Dopamine receptors activate different effectors through not only G-protein coupling, but also signaling through different protein (dopamine receptor-interacting proteins) interactions. [1]

  5. Ozempic May Help You Cut Back On Alcohol. Here's Why.

    www.aol.com/ozempic-may-help-cut-back-180600586.html

    Other studies found that rats given a GLP-1 agonist drank less alcohol, and their brains were less affected by dopamine when they ... smoking work by binding to nicotine receptors in the brain ...

  6. Short-term effects of alcohol consumption - Wikipedia

    en.wikipedia.org/wiki/Short-term_effects_of...

    Alcohol has a powerful effect on glutamate as well. Alcohol decreases glutamate's ability to bind with NMDA and acts as an antagonist of the NMDA receptor, which plays a critical role in LTP by allowing Ca2+ to enter the cell. These inhibitory effects are thought to be responsible for the "memory blanks" that can occur at levels as low as 0.03% ...

  7. Cross-tolerance - Wikipedia

    en.wikipedia.org/wiki/Cross-tolerance

    It is likely that this mechanism of cross-tolerance involves the dopamine receptor D 1. [4] Amphetamines also have cross-tolerance with pseudoephedrine, as pseudoephedrine can block dopamine uptake in the same manner that amphetamines do, but less potently. [5] Alcohol is another substance that often cross-tolerates with other drugs.

  8. Alcohol (drug) - Wikipedia

    en.wikipedia.org/wiki/Alcohol_(drug)

    Alcohol (from Arabic al-kuḥl 'the kohl'), [11] sometimes referred to by the chemical name ethanol, is the second most consumed psychoactive drug globally behind caffeine. [12] Alcohol is a central nervous system (CNS) depressant, decreasing electrical activity of neurons in the brain. [13]

  9. Alcohol withdrawal syndrome - Wikipedia

    en.wikipedia.org/wiki/Alcohol_withdrawal_syndrome

    Alcohol depresses the central nervous system, slowing cerebral messaging and altering the way signals are sent and received. Progressively larger amounts of alcohol are needed to achieve the same physical and emotional results. The drinker eventually must consume alcohol just to avoid the physical cravings and withdrawal symptoms.