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In the treatment of organophosphate toxicity, cholinesterase reactivators such as Pralidoxime reactivate inhibited AChE at peripheral nicotinic receptors.Since AChE mediates effects on both nicotinic and muscarinic receptors, cholinesterase reactivators are co-administered with muscarinic antagonists, primarily atropine.
Organophosphate poisoning is poisoning due to organophosphates (OPs). [4] Organophosphates are used as insecticides , medications, and nerve agents . [ 4 ] Symptoms include increased saliva and tear production, diarrhea , vomiting, small pupils , sweating, muscle tremors, and confusion. [ 2 ]
Asoxime chloride, or more commonly HI-6, is a Hagedorn oxime used in the treatment of organophosphate poisoning. [1] See also. Obidoxime; Pralidoxime; References
Pralidoxime (2-pyridine aldoxime methyl chloride) or 2-PAM, usually as the chloride or iodide salts, belongs to a family of compounds called oximes that bind to organophosphate-inactivated acetylcholinesterase. [1] It is used to treat organophosphate poisoning [2] in conjunction with atropine and either diazepam or midazolam. It is a white solid.
Obidoxime is a member of the oxime family used to treat organophosphate poisoning. Oximes are drugs known for their ability to reverse the binding of organophosphorus compounds to the enzyme acetylcholinesterase (AChE). [1] AChE is an enzyme that removes acetylcholine from the synapse after it creates the required stimulation on the next nerve ...
metronidazole – antibiotic against anaerobic bacteria; milbemycin oxime – broad spectrum antiparasitic used as an anthelmintic, insecticide and miticide; mirtazapine – antiemetic and appetite stimulant in cats and dogs; mitratapide – used to help weight loss in dogs; morphine – pure mu agonist/opioid analgesic used as a premedication
Organophosphate toxicity is classically associated with acetylcholinesterase inhibition. Acetylcholinesterase is an enzyme responsible for breaking down the neurotransmitter acetylcholine . Many organophosphates, especially those designed to act as nerve agents or pesticides, bind with the active site on acetylcholinesterase, preventing it from ...
The toxicity of chlorfenvinphos is primarily caused by its inhibition of cholinesterase activity. Chlorfenvinphos reacts with the acetylcholine binding sites of enzymes that hydrolyze acetylcholine, thereby preventing their catalysis of this reaction. The reaction itself is a phosphorylation, which is reversible. The phosphorylated enzymes can ...
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