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Dried blood spot testing (DBS) is a form of biosampling where blood samples are blotted and dried on filter paper. The dried samples can easily be shipped to an analytical laboratory and analysed using various methods such as DNA amplification or high-performance liquid chromatography .
With this testing methodology, newborn screening required one test to detect one condition. As mass spectrometry became more widely available, the technology allowed rapid determination of a number of acylcarnitines and amino acids from a single dried blood spot. This increased the number of conditions that could be detected by newborn screening.
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AI can potentially spot much more from a blood test than currently possible [Getty Images] This is the third feature in a six-part series that is looking at how AI is changing medical research and ...
whole blood: venipuncture: requires phlebotomist to collect Dried blood spot: gives high quality DNA and RNA Fingerstick: stores easily for years at room temperature organ tissue gives high quality DNA, RNA, Mitochondrial DNA, and source of disease Biopsy: many uses shared with blood; also suitable for proteomic analysis; may be difficult to ...
The blood of a two-week-old infant is collected for a Phenylketonuria, or PKU, screening. The neonatal heel prick is a blood collection procedure done on newborns. It consists of making a pinprick puncture in one heel of the newborn to collect their blood. This technique is used frequently as the main way to collect blood from neonates.
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