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Cryopreservation or cryoconservation is a process where biological material - cells, tissues, or organs - are frozen to preserve the material for an extended period of time. [1] At low temperatures (typically −80 °C (−112 °F) or −196 °C (−321 °F) using liquid nitrogen ) any cell metabolism which might cause damage to the biological ...
Women diagnosed with cancer who have not yet begun chemotherapy or radiotherapy can benefit from Oocyte cryopreservation. [3] Chemotherapy and radiotherapy are toxic to oocytes, reducing the number of viable eggs. Egg-freezing may be used in this case to preserve eggs as opposed to Oocyte cryopreservation. [clarification needed] [citation needed]
In 2004 Jacques Donnez in Belgium reported the first successful birth from frozen tissue using a protocol developed in Roger Gosden’s laboratory, where Oktay had studied. In 1997 samples of ovarian cortex were taken from a woman with Hodgkin's lymphoma and cryopreserved by slow freezing (Planer, UK) for banking in liquid nitrogen.
At least six major areas of cryobiology can be identified: 1) study of cold-adaptation of microorganisms, plants (cold hardiness), and animals, both invertebrates and vertebrates (including hibernation), 2) cryopreservation of cells, tissues, gametes, and embryos of animal and human origin for (medical) purposes of long-term storage by cooling to temperatures below the freezing point of water.
Stem-cell therapy uses stem cells to treat or prevent a disease or condition. [1] As of 2024, the only FDA-approved therapy using stem cells is hematopoietic stem cell transplantation. [2] [3] This usually takes the form of a bone marrow or peripheral blood stem cell transplantation, but the cells can also be derived from umbilical cord blood.
Patients are typically offered testing if they have either a personal or family history of cancer that meets certain criteria, Zakalik adds. Those criteria have broadened over the last few years ...
The cancer stem cell model, also known as the Hierarchical Model proposes that tumors are hierarchically organized (CSCs lying at the apex [6] (Fig. 3).) Within the cancer population of the tumors there are cancer stem cells (CSC) that are tumorigenic cells and are biologically distinct from other subpopulations [7] They have two defining features: their long-term ability to self-renew and ...
Peripheral blood stem cell transplantation (PBSCT), also called "Peripheral stem cell support", [1] is a method of replacing blood-forming stem cells.Stem cells can be destroyed through cancer treatments such as chemotherapy or radiation, as well as any blood-related diseases, such as leukemia, lymphoma, neuroblastoma and multiple myeloma. [2]
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