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In vivo studies of isolated anti-GM1 and GD3 antibodies indicate the antibodies can interfere with motor neuron function. [2] Anti-GD1a antibodies were highly associated acute motor axonal neuropathy while high titers of anti-GM1 were more frequent indicating that GD1a possibly targets the axolemma and nodes of Ranvier [ 3 ] most of the Ab+ ...
Antibodies to GM1 are increased in Guillain–Barré syndrome, dementia and lupus but their function is not clear. [4] There is some evidence to suggest antibodies against GM1 are associated with diarrhea in Guillain–Barré syndrome. [5] GM1 antibodies are also seen in Multifocal Motor Neuropathy (MMN), a rare antibody-mediated inflammatory ...
The GM1 gangliosidoses, usually shortened to GM1, are gangliosidoses caused by mutation in the GLB1 gene resulting in a deficiency of beta-galactosidase.The deficiency causes abnormal storage of acidic lipid materials in cells of the central and peripheral nervous systems, but particularly in the nerve cells, resulting in progressive neurodegeneration.
A ganglioside is a molecule composed of a glycosphingolipid (ceramide and oligosaccharide) with one or more sialic acids (e.g. N-acetylneuraminic acid, NANA) linked on the sugar chain. NeuNAc, an acetylated derivative of the carbohydrate sialic acid, makes the head groups of gangliosides anionic at pH 7, which distinguishes them from globosides .
Antibodies may be directed against "GM-1", a ganglioside found at the Nodes of Ranvier. These antibodies have been detected in at least one-third of MMN patients. More recent studies also suggest that newer tests for antibodies directed against GM-1, as well as a number of related gangliosides, are positive in over 80% of MMN patients.
Blood tests are also often used to identify associated antibodies. "About 80% of patients with MG are positive" for the antibody behind the immune system dysfunction, says Weidmayer.
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