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Causes may include sepsis, pancreatitis, trauma, pneumonia, and aspiration. [1] The underlying mechanism involves diffuse injury to cells which form the barrier of the microscopic air sacs of the lungs , surfactant dysfunction, activation of the immune system , and dysfunction of the body's regulation of blood clotting . [ 5 ]
Infant respiratory distress syndrome (IRDS), also known as surfactant deficiency disorder (SDD), [2] and previously called hyaline membrane disease (HMD), is a syndrome in premature infants caused by developmental insufficiency of pulmonary surfactant production and structural immaturity in the lungs.
Overview of signal transduction pathways involved in apoptosis. Cell death is the event of a biological cell ceasing to carry out its functions. This may be the result of the natural process of old cells dying and being replaced by new ones, as in programmed cell death, or may result from factors such as diseases, localized injury, or the death of the organism of which the cells are part.
The primary cause triggers an uncontrolled inflammatory response. [citation needed] Sepsis is the most common cause of multiple organ dysfunction syndrome and may result in septic shock. In the absence of infection, a sepsis-like disorder is termed systemic inflammatory response syndrome (SIRS). Both SIRS and sepsis could ultimately progress to ...
Type A: augmented pharmacological effects, which are dose-dependent and predictable [5]; Type A reactions, which constitute approximately 80% of adverse drug reactions, are usually a consequence of the drug's primary pharmacological effect (e.g., bleeding when using the anticoagulant warfarin) or a low therapeutic index of the drug (e.g., nausea from digoxin), and they are therefore predictable.
The cause is not fully understood, but evidence suggests that raised oxygen levels at the lens may be caused by deterioration of the vitreous humour due to age, and this causes degradation of lens crystallins by cross-linking, forming aggregates capable of scattering light. This may be an end-state development of the more commonly observed ...
In science and engineering, root cause analysis (RCA) is a method of problem solving used for identifying the root causes of faults or problems. [1] It is widely used in IT operations, manufacturing, telecommunications, industrial process control, accident analysis (e.g., in aviation, [2] rail transport, or nuclear plants), medical diagnosis, the healthcare industry (e.g., for epidemiology ...
Loss end states can be any state at the end of the pathway that is a negative outcome of the initiating event. The loss end state is highly dependent upon the system, for example if you were measuring a quality process in a factory a loss or end state would be that the product has to be reworked or thrown in the trash. Some common loss end ...