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Like many other medical conditions, obesity is the result of an interplay between environmental and genetic factors. [2] [3] Studies have identified variants in several genes that may contribute to weight gain and body fat distribution, although only in a few cases are genes the primary cause of obesity.
Fat mass and obesity-associated protein, also known as alpha-ketoglutarate-dependent dioxygenase FTO, is an enzyme that in humans is encoded by the FTO gene located on chromosome 16. As one homolog in the AlkB family proteins, it is the first messenger RNA (mRNA) demethylase that has been identified. [ 5 ]
Pelvic lipomatosis — A rare disease most often seen in older obese black men with hypertension. Virchow's metamorphosis — lipomatosis in the heart and salivary glands. Dercums — A rare condition characterized by generalized obesity and painful fatty tumors in the adipose tissue.
Monogenic obesity is excess weight caused by a mutation in a single gene, as opposed to syndromic obesity not tied to a single gene variation and most obesity, which is caused by multiple genetic and environmental risk factors. Monogenetic obesity mostly affects the hypothalamus and leptin–melanocortin system (see hypothalamic obesity ...
Some 38% of men and 40% of women in the study had a BMI of 30 or more by WHO’s standards. When body fat percentage was factored in, this jumped to 71% of men and 64% of women.
Obesity is a disease characterized by having excessive body fat, increasing a person’s risk for many serious health problems, such as heart disease, diabetes, and even some cancers.
Research shows that older men and women with low testosterone have lower red blood cell counts and an increased risk of developing anemia. Anemia can produce symptoms like fatigue, weakness, loss ...
The following is a list of genetic disorders and if known, type of mutation and for the chromosome involved. Although the parlance "disease-causing gene" is common, it is the occurrence of an abnormality in the parents that causes the impairment to develop within the child.
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