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  2. Gap junction modulator - Wikipedia

    en.wikipedia.org/wiki/Gap_junction_modulator

    A gap junction modulator is a compound or agent that either facilitates or inhibits the transfer of small molecules between biological cells by regulating gap junctions. [1] Various physiological processes including cardiac , neural or auditory , depend on gap junctions to perform crucial regulatory roles, and the modulators themselves are the ...

  3. Gap junction - Wikipedia

    en.wikipedia.org/wiki/Gap_junction

    Gap junctions were first described as close appositions as other tight junctions, but following electron microscopy studies in 1967, they were renamed gap junctions to distinguish them from tight junctions. [2] They bridge a 2-4 nm gap between cell membranes. [3] Gap junctions use protein complexes known as connexons to

  4. Gap junction modulation - Wikipedia

    en.wikipedia.org/wiki/Gap_Junction_Modulation

    Gap junctions play an important regulatory role in various physiological processes including signal propagation in cardiac muscles and tissue homeostasis of the liver. Modulation is required, since gap junctions must respond to their environment, whether through an increased expression or permeability.

  5. Cell–cell interaction - Wikipedia

    en.wikipedia.org/wiki/Cell–cell_interaction

    Gap junctions are the main site of cell-cell signaling or communication that allow small molecules to diffuse between adjacent cells. In vertebrates, gap junctions are composed of transmembrane proteins called connexins. They form hexagonal pores or channels through which ions, sugars, and other small molecules can pass.

  6. Cell junction - Wikipedia

    en.wikipedia.org/wiki/Cell_junction

    Gap junctions play vital roles in the human body, [11] including their role in the uniform contractile of the heart muscle. [11] They are also relevant in signal transfers in the brain, and their absence shows a decreased cell density in the brain. [12] Retinal and skin cells are also dependent on gap junctions in cell differentiation and ...

  7. Connexon - Wikipedia

    en.wikipedia.org/wiki/Connexon

    Gap junctions are often present at nerve endings such as in cardiac muscle and are important in maintaining homeostasis in the liver and proper function of the kidneys. The gap junction itself is a structure that is a specialized transmembrane protein formed by a connexon hemichannel. [ 8 ]

  8. GJB2 - Wikipedia

    en.wikipedia.org/wiki/GJB2

    Gap junction beta-2 protein is a member of the connexin protein family and plays a crucial role in forming gap junctions, which are channels that allow the transport of nutrients, ions, and signaling molecules between adjacent cells. [6] GJB2 is widely expressed throughout the body, with particularly important functions in the inner ear and skin.

  9. GJA1 - Wikipedia

    en.wikipedia.org/wiki/GJA1

    Gap junction alpha-1 protein (GJA1), also known as connexin 43 (Cx43), is a protein that in humans is encoded by the GJA1 gene on chromosome 6. [ 5 ] [ 6 ] [ 7 ] As a connexin , GJA1 is a component of gap junctions , which allow for gap junction intercellular communication (GJIC) between cells to regulate cell death , proliferation , and ...