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Iron overload (also known as haemochromatosis or hemochromatosis) is the abnormal and increased accumulation of total iron in the body, leading to organ damage. [1] The primary mechanism of organ damage is oxidative stress, as elevated intracellular iron levels increase free radical formation via the Fenton reaction.
Haemochromatosis is protean in its manifestations, i.e., often presenting with signs or symptoms suggestive of other diagnoses that affect specific organ systems.Many of the signs and symptoms below are uncommon, and most patients with the hereditary form of haemochromatosis do not show any overt signs of disease nor do they have premature morbidity, if they are diagnosed early, but, more ...
The senior dog population consists of dogs that are over the age of seven for most dog breeds, [1] though in general large and giant breed dogs tend to reach this life stage earlier when compared to smaller breed dogs. Senior dog foods contain nutrients and characteristics that are used to improve the health of the aging dog.
Studies indicate that dogs given a whole-food diet when young have fewer yeast infections in the ears and that the incidence of ear infections may decrease as the dogs become older (1).
Treatment for hemochromatosis type 3 may include reducing iron levels by removing blood (phlebotomy), iron chelation therapy, diet changes, and treatment for complications of the disease. The purpose of the treatment is to reduce the amount of iron in the body to normal levels, prevent or delay organ damage from excess iron, and maintain normal ...
When looking for a senior dog food, one of the first things that should be taken into consideration is the energy content of the diet. The maintenance energy requirements decrease as a dog ages due to the loss in lean body mass that occurs. [63] Therefore, senior dogs will require a diet with a lowered energy content compared to non senior diets.
During growth, young dogs are more susceptible to infection, but the addition of proper levels of vitamin E to the diet reduces free radical oxidative damage and leads to an increase in immunity. Calcium and phosphorus, in the appropriate amounts and ratio, aid in proper bone and cartilage growth and maturation.
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