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Naltrexone/bupropion, sold under the brand name Contrave among others, is a fixed-dose combination medication for the management of chronic obesity in adults in combination with a reduced-calorie diet and increased physical activity. [4] [6] It contains naltrexone, an opioid antagonist, and bupropion, an aminoketone atypical antidepressant. [4]
Bupropion, when used for treating long-term weight gain over six to twelve months, results in an average weight loss of 2.7 kilograms (6.0 lb) over placebo. [74] This is not much different from the weight loss produced by several other weight-loss medications such as sibutramine or orlistat . [ 74 ]
A systematic review published in the journal Obesity Reviews in 2019 found that just about all of the widely-used medications for depression resulted in long-term weight gain, with the exception ...
[1] [3] [4] [5] The scores shown are the mean total depression scores on the MADRS over 6 weeks. Only 124/156 patients completed 6 weeks of Auvelity while 150/162 patients completed 6 weeks of placebo, consistent with a high rate of adverse reactions. [4] [5] [2] Dextromethorphan/bupropion is approved for the treatment of major depressive ...
Regular physical activity can help accelerate weight loss, improve metabolism and enhance the benefits of weight loss pills. Aim for 150 minutes per week (or about a half-hour five days a week).
Typically, the recommended starting dosage for Wellbutrin is 200mg per day, with a maximum dosage of 450mg per day. The starting dosage is taken as 100mg twice per day.
Bupropion/zonisamide (former tentative brand name Empatic, Excalia) is an experimental combination of bupropion which was under development for the treatment of obesity. [1] [2] [3] Bupropion is a norepinephrine–dopamine reuptake inhibitor and nicotinic acetylcholine receptor antagonist, while zonisamide is an anticonvulsant acting as a sodium channel blocker, T-type calcium channel blocker ...
Weight gain. Some side effects, such as weight gain, occur more frequently with certain types of antidepressant medication. Switching to a new type of antidepressant may help reverse any weight ...
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