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[19] [17] LSD was the 25th of various lysergamides Hofmann synthesized from lysergic acid while trying to develop a new analeptic, hence the alternate name LSD-25. Hofmann discovered its effects in humans on April 16, in 1943, after unintentionally ingesting an unknown amount, possibly absorbing it through his skin.
Like ALD-52, 1P-LSD is believed to act as a prodrug for LSD via hydrolysis of the propionyl group. When 1P-LSD is incubated in human serum, [10] administered intravenously to rats, [11] or administered either orally or intravenously to human subjects, [12] high levels of LSD and relatively low levels of 1P-LSD are quickly detected, demonstrating that 1P-LSD is rapidly hydrolyzed into LSD in ...
1S-LSD (1-(3-(trimethylsilyl)propionyl)-lysergic acid diethylamide) is a psychotropic substance and research chemical belonging to the lysergamide class. It is the trimethylsilyl derivative of 1P-LSD and functions as a prodrug and functional analogue of LSD.
Lysergic acid 2-butyl amide (2-Butyllysergamide, LSB) is an analogue of LSD originally developed by Richard Pioch at Eli Lilly in the 1950s, [2] but mostly publicised through research conducted by the team led by David E. Nichols at Purdue University.
LSD made a comeback in the 1980s accompanying the advent of recreational MDMA use, first in the punk and gothic subcultures through dance clubs, then in the 1990s through the acid house scene and rave subculture. LSD use and availability declined sharply following a raid of a large scale LSD lab in 2000 (see LSD in the United States).
1V-LSD (1-valeryl-D-lysergic acid diethylamide), sometimes nicknamed Valerie, is a psychotropic substance and a research chemical with psychedelic effects. [1] [2] 1V-LSD is an artificial derivative of natural lysergic acid, which occurs in ergot alkaloids, as well as being an analogue of LSD.
1cP-LSD (N1-(cyclopropylmethanoyl)-lysergic acid diethylamide) is an acylated derivative of lysergic acid diethylamide , which has been sold as a designer drug. [ 1 ] [ 2 ] It was first synthesized as a legal- LSD alternative by Lizard Labs , a Netherlands based research chemical laboratory. [ 3 ]
Hypnodelic therapy, as the name suggests, was developed with the goal to maximize the power of hypnotic suggestion by combining it with the psychedelic experience. After training the patient to respond to hypnosis, LSD would be administered, and during the onset phase of the drug the patient would be placed into a state of trance.