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LSD is a chiral compound with two stereocenters at the carbon atoms C-5 and C-8, so that theoretically four different optical isomers of LSD could exist. LSD, also called (+)-d-LSD, [136] has the absolute configuration (5R,8R). 5S stereoisomers of lysergamides do not exist in nature and are not formed during the synthesis from d-lysergic acid.
Descarboxylysergic acid, or 8-descarboxylysergic acid, also known as 9,10-didehydro-6-methylergoline or as 6-methyl-9-ergolene, is a drug of the ergoline family related to lysergic acid and lysergamides like lysergic acid diethylamide (LSD).
1S-LSD (1-(3-(trimethylsilyl)propionyl)-lysergic acid diethylamide) is a psychotropic substance and research chemical belonging to the lysergamide class. It is the trimethylsilyl derivative of 1P-LSD and functions as a prodrug and functional analogue of LSD.
Lysergic acid, also known as D-lysergic acid and (+)-lysergic acid, is a precursor for a wide range of ergoline alkaloids that are produced by the ergot fungus and found in the seeds of Argyreia nervosa (Hawaiian baby woodrose), and Ipomoea species (morning glories, ololiuhqui, tlitliltzin).
LSD made a comeback in the 1980s accompanying the advent of recreational MDMA use, first in the punk and gothic subcultures through dance clubs, then in the 1990s through the acid house scene and rave subculture. LSD use and availability declined sharply following a raid of a large scale LSD lab in 2000 (see LSD in the United States).
1cP-LSD (N1-(cyclopropylmethanoyl)-lysergic acid diethylamide) is an acylated derivative of lysergic acid diethylamide , which has been sold as a designer drug. [ 1 ] [ 2 ] It was first synthesized as a legal- LSD alternative by Lizard Labs , a Netherlands based research chemical laboratory. [ 3 ]
Lysergic acid 2-butyl amide (2-Butyllysergamide, LSB) is an analogue of LSD originally developed by Richard Pioch at Eli Lilly in the 1950s, [2] but mostly publicised through research conducted by the team led by David E. Nichols at Purdue University.
ALD-52, also known as 1-acetyl-LSD, has chemical structural features similar to lysergic acid diethylamide (LSD), a known psychedelic drug. [ 3 ] [ 4 ] Similarly, ALD-52 has been reported to produce psychoactive effects, but its pharmacological effects on humans are poorly understood.