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LSD is a chiral compound with two stereocenters at the carbon atoms C-5 and C-8, so that theoretically four different optical isomers of LSD could exist. LSD, also called (+)-d-LSD, [137] has the absolute configuration (5R,8R). 5S stereoisomers of lysergamides do not exist in nature and are not formed during the synthesis from d-lysergic acid.
1cP-LSD (N1-(cyclopropylmethanoyl)-lysergic acid diethylamide) is an acylated derivative of lysergic acid diethylamide , which has been sold as a designer drug. [ 1 ] [ 2 ] It was first synthesized as a legal- LSD alternative by Lizard Labs , a Netherlands based research chemical laboratory. [ 3 ]
The LSD is taken first, followed by the MDMA 4 hours later and then 2C-B is taken 2 hours after the MDMA ( so 6 hours after the LSD ). MDMA can be replaced by 6-APB, 5-APB, 6-MAPB or 5-MAPB, in this case the Empathogen is taken 2 hours after the LSD, while 2C-B may be replaced by 2C-C, 2C-D or 2C-B-FLY.
1S-LSD (1-(3-(trimethylsilyl)propionyl)-lysergic acid diethylamide) is a psychotropic substance and research chemical belonging to the lysergamide class. It is the trimethylsilyl derivative of 1P-LSD and functions as a prodrug and functional analogue of LSD.
Like ALD-52, 1P-LSD is believed to act as prodrug for LSD via hydrolysis of the propionyl group. When 1P-LSD is incubated in human serum, [10] administered intravenously to rats, [11] or administered either orally or intravenously to human subjects, [12] high levels of LSD and relatively low levels of 1P-LSD are quickly detected, demonstrating that 1P-LSD is rapidly hydrolyzed into LSD in vivo ...
LSD made a comeback in the 1980s accompanying the advent of recreational MDMA use, first in the punk and gothic subcultures through dance clubs, then in the 1990s through the acid house scene and rave subculture. LSD use and availability declined sharply following a raid of a large scale LSD lab in 2000 (see LSD in the United States).
ALD-52, also known as 1-acetyl-LSD, has chemical structural features similar to lysergic acid diethylamide (LSD), a known psychedelic drug. [ 3 ] [ 4 ] Similarly, ALD-52 has been reported to produce psychoactive effects, but its pharmacological effects on humans are poorly understood.
Lysergic acid 2-butyl amide (2-Butyllysergamide, LSB) is an analogue of LSD originally developed by Richard Pioch at Eli Lilly in the 1950s, [2] but mostly publicised through research conducted by the team led by David E. Nichols at Purdue University.