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Pyridoxine/doxylamine, sold under the brand name Diclectin among others, is a combination of pyridoxine hydrochloride (vitamin B 6) and doxylamine succinate.It is generally used for nausea and vomiting of pregnancy (morning sickness); even though its efficacy has not been proven and subsequent research has led to the removal of recommendations in medical journals.
Morning sickness, also called nausea and vomiting of pregnancy (NVP), is a symptom of pregnancy that involves nausea or vomiting. [1] Despite the name, nausea or vomiting can occur at any time during the day. [2] Typically the symptoms occur between the 4th and 16th weeks of pregnancy. [2]
Vomiting is a common condition affecting about 50% of pregnant women, with another 25% having nausea. [53] However, the incidence of HG is only 0.3–1.5%. [ 4 ] After preterm labor, hyperemesis gravidarum is the second most common reason for hospital admission during the first half of pregnancy. [ 16 ]
Doxylamine is used in the combination drug pyridoxine/doxylamine to treat morning sickness (nausea and vomiting of pregnancy). [ 19 ] [ 20 ] [ 21 ] It is the only medication approved by the United States Food and Drug Administration for the treatment of morning sickness.
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Although described as "morning sickness," pregnant women can experience this nausea any time of day or night. The exact cause of morning sickness remains unknown. Nausea and vomiting in pregnancy is typically mild and self-limited, resolving on its own by the 14th week of pregnancy. Other causes should also be ruled out when considering treatment.
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Nausea and vomiting associated with migraine headaches respond best to dopamine antagonists such as metoclopramide, prochlorperazine, and chlorpromazine. [22] In cases of gastroenteritis, serotonin antagonists such as ondansetron were found to suppress nausea and vomiting, as well as reduce the need for IV fluid resuscitation. [ 22 ]
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