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Vitamin B 12 deficiency, also known as cobalamin deficiency, is the medical condition in which the blood and tissue have a lower than normal level of vitamin B 12. [5] Symptoms can vary from none to severe. [1] Mild deficiency may have few or absent symptoms. [1]
Lack of vitamin B12 can cause megaloblastic anemia—a condition characterized by larger than normal red blood cells in a smaller than normal amount. This causes fatigue, paleness in the skin ...
Vitamin B 12 was discovered as a result of pernicious anemia, an autoimmune disorder in which the blood has a lower than normal number of red blood cells, due to a deficiency of vitamin B 12. [ 5 ] [ 16 ] The ability to absorb the vitamin declines with age, especially in people over 60.
Someone within "normal" B12 limits, might do fine with taking their B12 in a multivitamin, Cording says. "If they have a noted deficiency, I might put them on a higher dose—500 micrograms or ...
If there are other, reversible causes of low vitamin B 12 levels, the cause must be treated. [106] Vitamin B 12 deficiency anemia is usually easily treated by providing the necessary level of vitamin B 12 supplementation. [107] The injections are quick-acting, and symptoms usually go away within one to two weeks. [107]
Vitamin B12 deficiency symptoms . Vitamin B12 deficiency has a few hallmark symptoms, according to doctors: Lack of energy. Mental fatigue. Nausea, vomiting, or diarrhea. Lack of appetite. Weight loss
[56] [57] Low levels of serum vitamin B 12 may be caused by other factors than B 12 deficiency, such as folate deficiency, pregnancy, oral contraceptive use, haptocorrin deficiency, and myeloma. [57] High serum levels may caused by supplementing with vitamin B 12, present of antibodies to intrinsic factor, or due to underlying condition. [56]
Serum vitamin B 12 is a medical laboratory test that measure vitamin B 12 only in the blood binding to both transcobalamins. [1] Most of the time, 80–94% of vitamin B 12 in the blood binds to haptocorrin, while only 6–20% is binds to transcobalamin ll. [2] Only transcobalamin ll is "active" and can be used by the body. [1]
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