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The Disabled-1 (Dab1) gene encodes a key regulator of Reelin signaling. Reelin is a large glycoprotein secreted by neurons of the developing brain, particularly Cajal-Retzius cells . DAB1 functions downstream of Reln in a signaling pathway that controls cell positioning in the developing brain and during adult neurogenesis .
The spontaneous autosomal recessive scrambler mutation on chromosome 4 causes a deficiency of DAB1, encoding disabled-1, a protein involved in the signaling of the Reelin protein, lacking in the reeler mutant, [3] Dab1-scm homozygous mutants possess a reeler-like phenotype with respect to cell malpositioning in cerebellar cortex, hippocampus, and neocortex.
CR cells secrete the extracellular matrix protein reelin, which is critically involved in the control of radial neuronal migration through a signaling pathway, including the very low density lipoprotein receptor (VLDLR), the apolipoprotein E receptor type 2 (ApoER2), and the cytoplasmic adapter protein disabled 1 (Dab1).
The yotari mouse is an autosomal recessive mutant. [1] It has a mutated disabled homolog 1 ( Dab1 ) gene. [ 2 ] This mutant mouse is recognized by unstable gait ("Yota-ru" in Japanese means "unstable gait") and tremor and by early deaths around the time of weaning .
Not long after finding George in the end zone, Ward got TD No. 157 with a 22-yard TD pass to Joshisa Trader early in the second quarter. Ward finished the first half 12-of-19 passing for 190 yards ...
Gotham has Batman, but New York wants Robin. Senate Majority Leader Chuck Schumer, D-N.Y., said this weekend that the Department of Homeland Security should send special drone-detection technology ...
Connecticut is known for being an expensive place to live. And that’s especially true if you’re a homeowner. Known as the Constitution State, Connecticut has an average property tax rate of 1.54%.
A LifeCam HD-3000 webcam sitting on top of a monitor. The LifeCam is a lineup of webcams from Microsoft for PC users marketed since 2006. Various models and series of webcams are designed for either laptops or desktops.