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  2. CD68 - Wikipedia

    en.wikipedia.org/wiki/CD68

    CD68 immunostaining demonstrating macrophages and giant cells in a case of xanthogranulomatous pyelonephritis CD68 ( C luster of D ifferentiation 68) is a protein highly expressed by cells in the monocyte lineage (e.g., monocytic phagocytes , osteoclasts ), by circulating macrophages , and by tissue macrophages (e.g., Kupffer cells , microglia ).

  3. Lysosome-associated membrane glycoprotein - Wikipedia

    en.wikipedia.org/wiki/Lysosome-associated...

    Structurally, the lamp proteins consist of two internally homologous lysosome-luminal domains separated by a proline-rich hinge region; at the C-terminal extremity there is a transmembrane region (TM) followed by a very short cytoplasmic tail (C). In each of the duplicated domains, there are two conserved disulfide bonds. This structure is ...

  4. Histiocyte - Wikipedia

    en.wikipedia.org/wiki/Histiocyte

    Macrophages are highly variable in size and morphology, their cytoplasm contains numerous acid phosphatase laden lysosomes – in relation to their specialised phagocytic function. They express CD68. Dendritic cells have an indented (bean-shaped) nucleus and cytoplasm with thin processes (dendritic).

  5. LAMP1 - Wikipedia

    en.wikipedia.org/wiki/LAMP1

    Lysosomal-associated membrane protein 1 (LAMP-1) also known as lysosome-associated membrane glycoprotein 1 and CD107a (Cluster of Differentiation 107a), is a protein that in humans is encoded by the LAMP1 gene. The human LAMP1 gene is located on the long arm (q) of chromosome 13 at region 3, band 4 (13q34).

  6. Lysosome - Wikipedia

    en.wikipedia.org/wiki/Lysosome

    A lysosome (/ ˈ l aɪ s ə ˌ s oʊ m /) is a single membrane-bound organelle found in many animal cells. [1] [2] They are spherical vesicles that contain hydrolytic enzymes that digest many kinds of biomolecules. A lysosome has a specific composition, of both its membrane proteins and its lumenal proteins.

  7. Giant cell - Wikipedia

    en.wikipedia.org/wiki/Giant_cell

    Multinucleated giant cells due to an infection. H&E stain.. A giant cell (also known as a multinucleated giant cell, or multinucleate giant cell) is a mass formed by the union of several distinct cells (usually histiocytes), often forming a granuloma.

  8. Macrophage - Wikipedia

    en.wikipedia.org/wiki/Macrophage

    They can be identified using flow cytometry or immunohistochemical staining by their specific expression of proteins such as CD14, CD40, CD11b, CD64, F4/80 (mice)/EMR1 (human), lysozyme M, MAC-1/MAC-3 and CD68. [9] Macrophages were first discovered and named by Élie Metchnikoff, a Russian Empire zoologist, in 1884. [10] [11]

  9. CD63 - Wikipedia

    en.wikipedia.org/wiki/CD63

    The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains.

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