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Ibuprofen and acetaminophen, commonly known as Motrin or Advil, and Tylenol, can cause liver damage in dogs. Human antidepressant drugs like Celexa can cause neurological problems in dogs. ADHD medications contain stimulants, such as methylphenidate, that if ingested even in small amounts can be life-threatening to dogs. Examples are Concerta ...
Drug-induced liver injury (DILI) is a cause of acute and chronic liver disease caused specifically by medications and the most common reason for a drug to be withdrawn from the market after approval. The liver plays a central role in transforming and clearing chemicals and is susceptible to the toxicity from these agents.
The first reports of serious liver toxicity with nefazodone were published in 1998 and 1999. [40] [41] These instances were quickly followed by many additional cases. [42] [22] [23] [24] In 2002 the United States Food and Drug Administration (FDA) obligated BMS to add a black box warning about potential fatal liver toxicity to the drug label.
Shunting the issue - Liver shunts in dogs. This article will discuss what exactly a liver shunt is, how to recognize the signs of a liver shunt, what treatment options are available, and how to ...
Type A: augmented pharmacological effects, which are dose-dependent and predictable [5]; Type A reactions, which constitute approximately 80% of adverse drug reactions, are usually a consequence of the drug's primary pharmacological effect (e.g., bleeding when using the anticoagulant warfarin) or a low therapeutic index of the drug (e.g., nausea from digoxin), and they are therefore predictable.
Cinchophen is the main active ingredient in prednoleucotropin (PLT), a medication used in the treatment of osteoarthritis in dogs. [10] PLT may produce analgesic and anti-pyretic effects at higher doses. Osteoarthritic dogs treated with PLT have shown significant improvement of joint mobility, stiffness, lameness and weight bearing capacity. [11]
When Novartis tested imatinib in rats, mice, rabbits, dogs, and monkeys in 1996, it was found to have several toxic effects; in particular, results indicating liver damage in dogs nearly stopped drug development completely. However, favorable results in studies with monkeys and in vitro human cells allowed testing to continue in humans. [47 ...
The disease can be confused with canine parvovirus because both will cause a low white blood cell count and bloody diarrhea in young, unvaccinated dogs. Treatment is symptomatic. Most dogs recover spontaneously without treatment. Prevention is through vaccination (ATCvet code QI07AA05 and various combination vaccines).