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In such cases, a microbiology laboratory must run tests to determine which antibiotics will treat the infection. [24] More specific treatments of Klebsiella pneumonia are given in its section above. For urinary tract infections with multidrug-resistant Klebsiella species, a combination therapy with amikacin and meropenem has been suggested. [44]
Klebsiella aerogenes, [2] previously known as Enterobacter aerogenes, is a Gram-negative, oxidase-negative, catalase-positive, citrate-positive, indole-negative, rod-shaped bacterium. [3] Capable of motility via peritrichous flagella, [ 4 ] it is approximately one to three microns in length.
Amoxicillin is an antibiotic medication belonging to the aminopenicillin class of the penicillin family. The drug is used to treat bacterial infections [9] such as middle ear infection, strep throat, pneumonia, skin infections, odontogenic infections, and urinary tract infections. [9]
Thus the use of low-dose amoxicillin-clavulanate in combination with meropenem may be used in part of a treatment regimen for drug-resistant TB and this has been demonstrated in a clinical setting also.
Klebsiella pneumoniae includes numerous mechanisms for antibiotic resistance, many of which are located on highly mobile genetic elements. [30] Carbapenem antibiotics (heretofore often the treatment of last resort for resistant infections) are generally not effective against KPC-producing organisms. [31]
Klebsiella pneumoniae is a bacterium found in a person’s gut microbiome and feces. If K. pneumoniae travels to other areas of the body, it can cause a number of serious medical conditions.
The structure of a Streptomyces serine β-lactamase (SBLs) is given by 1BSG.The alpha-beta fold (InterPro: IPR012338) resembles that of a DD-transpeptidase, from which the enzyme is thought to have evolved. β-lactam antibiotics bind to DD-transpeptidases to inhibit bacterial cell wall biosynthesis.
Klebsiella causes a range of diseases like pneumonia and infections of the urinary tract, skin and wounds, and is responsible for about a fifth of all deaths attributed to drug-resistant superbugs.
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