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The table shown on the right can be used in a two-sample t-test to estimate the sample sizes of an experimental group and a control group that are of equal size, that is, the total number of individuals in the trial is twice that of the number given, and the desired significance level is 0.05. [4]
Matched or independent study designs may be used. Power, sample size, and the detectable alternative hypothesis are interrelated. The user specifies any two of these three quantities and the program derives the third. A description of each calculation, written in English, is generated and may be copied into the user's documents.
nQuery is a clinical trial design platform used for the design and monitoring of adaptive, group sequential, and fixed sample size trials. It is most commonly used by biostatisticians to calculate sample size and statistical power for adaptive clinical trial design. nQuery is proprietary software developed and distributed by Statsols. The ...
PASS is a computer program for estimating sample size or determining the power of a statistical test or confidence interval. NCSS LLC is the company that produces PASS. NCSS LLC also produces NCSS (for statistical analysis). PASS includes over 920 documented sample size and power procedures.
OpenEpi is a free, web-based, open source, operating system-independent series of programs for use in epidemiology, biostatistics, public health, and medicine, providing a number of epidemiologic and statistical tools for summary data.
If the sample size is 1,000, then the effective sample size will be 500. It means that the variance of the weighted mean based on 1,000 samples will be the same as that of a simple mean based on 500 samples obtained using a simple random sample.
Schematic block diagram of an adaptive design for a clinical trial [1] In an adaptive design of a clinical trial, the parameters and conduct of the trial for a candidate drug or vaccine may be changed based on an interim analysis. [2] [1] [3] Adaptive design typically involves advanced statistics to interpret a clinical trial endpoint. [1]
The sponsor of the clinical trial develops the CRF to collect the specific data they need in order to test their hypotheses or answer their research questions. The size of a CRF can range from a handwritten one-time 'snapshot' of a patient's physical condition to hundreds of pages of electronically captured data obtained over a period of weeks ...