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A conservative replacement (also called a conservative mutation or a conservative substitution or a homologous replacement) is an amino acid replacement in a protein that changes a given amino acid to a different amino acid with similar biochemical properties (e.g. charge, hydrophobicity and size). [1] [2]
Valine (symbol Val or V) [4] is an α-amino acid that is used in the biosynthesis of proteins. It contains an α-amino group (which is in the protonated −NH 3 + form under biological conditions), an α-carboxylic acid group (which is in the deprotonated −COO − form under biological conditions), and a side chain isopropyl group, making it a non-polar aliphatic amino acid.
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An excipient is a substance formulated alongside the active ingredient of a medication.They may be used to enhance the active ingredient’s therapeutic properties; to facilitate drug absorption; to reduce viscosity; to enhance solubility; to improve long-term stabilization (preventing denaturation and aggregation during the expected shelf life); or to add bulk to solid formulations that have ...
Extenders are distinguished from fillers by their high protein content, compared to the high carbohydrate content of fillers. Extenders were originally used to reduce costs, but they were later used to make meat products more healthy by adding dietary fiber , or to improve the texture. [ 2 ]
The neutral mutation rate is affected by the amount of neutral sites in a protein or DNA sequence versus the amount of mutation in sites that are functionally constrained. By quantifying these neutral mutations in protein and/or DNA and comparing them between species or other groups of interest, rates of divergence can be determined. [33] [36]
8140 20539 Ensembl ENSG00000103257 ENSMUSG00000040010 UniProt Q01650 Q9Z127 RefSeq (mRNA) NM_003486 NM_011404 RefSeq (protein) NP_003477 NP_035534 Location (UCSC) Chr 16: 87.83 – 87.87 Mb Chr 8: 122.61 – 122.63 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Large neutral amino acids transporter small subunit 1, also known as 4F2 light chain, or CD98 light chain is a protein that ...
Protein precipitation is widely used in downstream processing of biological products in order to concentrate proteins and purify them from various contaminants. For example, in the biotechnology industry protein precipitation is used to eliminate contaminants commonly contained in blood. [1]
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