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Like other SSRIs, sertraline is associated with sexual side effects, including sexual arousal disorder, erectile dysfunction and difficulty achieving orgasm. While nefazodone and bupropion do not have negative effects on sexual functioning, 67% of men on sertraline experienced ejaculation difficulties versus 18% before the treatment. [92]
Intimacy Problems. Sertraline and other SSRIs can cause a variety of intimacy side effects, from difficulty climaxing to decreased drive. According to a review of studies published in the journal ...
This side effect has been particularly associated with serotonergic antidepressants like SSRIs and SNRIs, but may be less with atypical antidepressants like bupropion, agomelatine, and vortioxetine. [ 83 ] [ 85 ] [ 86 ] Higher doses of antidepressants seem to be more likely to produce emotional blunting than lower doses. [ 83 ]
Many of these symptoms may be side effects of the drug or drug interaction causing excessive levels of serotonin rather than an effect of elevated serotonin itself. Tremor is a common side effect of MDMA's action on dopamine, whereas hyperreflexia is symptomatic of exposure to serotonin agonists.
Many SSRIs can cause intimate side effects, so the chance of experiencing adverse effects of sertraline (Zoloft) may be similar to experiencing Prozac’s intimate side effects.
Despite their side effects, some tricyclic antidepressants may be effective for improving depression symptoms when other, newer medications aren’t effective. Atypical antidepressants.
The effects on the CYP3A4 in the liver could, in principle, cause interactions with non-oral drugs (e.g. parenteral, inhaled substances, transdermal), [citation needed] and non-CYP3A4-mediated effects also exist. [31] Cytochrome isoforms affected by grapefruit components include CYP3A4, CYP1A2, CYP2C9, and CYP2D6. [21]
Intimate Side Effects of Zoloft TL;DR. Zoloft is a brand-name antidepressant also known generically as sertraline. Sertraline is a selective serotonin reuptake inhibitor prescribed to treat ...