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The LD 50 of nicotine is 50 mg/kg for rats and 3 mg/kg for mice. 0.5–1.0 mg/kg can be a lethal dosage for adult humans, and 0.1 mg/kg for children. [19] [20] However the widely used human LD 50 estimate of 0.5–1.0 mg/kg was questioned in a 2013 review, in light of several documented cases of humans surviving much higher doses; the 2013 review suggests that the lower limit causing fatal ...
It may be drunk accidentally or intentionally in a suicide attempt. [2] When broken down by the body it results in glycolic acid and oxalic acid which cause most of the toxicity. [1] [4] The diagnosis may be suspected when calcium oxalate crystals are seen in the urine or when acidosis or an increased osmol gap is present in the blood. [1]
Conditions which disrupt coordination of swallowing above the glottis put a patient at increased risk for aspiration. This is referred to as oropharyngeal dysphagia and can be a result of structural abnormalities ( strictures , stenosis, mediastinal and neck masses, etc.), connective tissue diseases, neuropathy, or other central nervous system ...
A former inmate convicted of smuggling illegal drugs into Bucks County jail that resulted in the overdose death of a prisoner is alleging that he nearly died last year after corrections employees ...
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Tobacco plant. Green Tobacco Sickness (GTS) is a type of nicotine poisoning caused by the transdermal absorption of nicotine from the surface of tobacco plants. [1] Tobacco plants that have yet to be cured are referred to as "green tobacco".
Nicotine promotes the growth of blood vessels, which can supply tumors and speed tumor growth. [76] As of 2015, long-term vaping had not been assessed for malignancy in individuals with a susceptibility for tumor growth. [138] The effects of nicotine on the sympathoadrenal system could stimulate growth in cancers already present. [221]