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The synthesis of 6-acetyl-1,2,3,4-tetrahydropyridine, an important bread aroma compound, starting from 2-piperidone was accomplished using t-boc anhydride. [14] See Maillard reaction ). The first step in this reaction sequence is the formation of the carbamate from the reaction of the amide nitrogen with boc anhydride in acetonitrile using DMAP ...
tert-Butyloxycarbonyl protecting group. The tert-butyloxycarbonyl protecting group or tert-butoxycarbonyl protecting group [1] (BOC group) is an acid-labile protecting group used in organic synthesis. The BOC group can be added to amines under aqueous conditions using di-tert-butyl dicarbonate in the presence of a base such as sodium hydroxide:
1 mono- 30 triaconta- 2 di- 31 hentriaconta- 3 tri- 32 dotriaconta- 4 tetra- 33 tritriaconta- 5 penta- 34 tetratriaconta- 6 hexa- 40 tetraconta- 7 hepta- 50 pentaconta- 8 octa- 60 hexaconta- 9 nona- 70 heptaconta- 10 deca- 80 octaconta- 11 undeca- 90 nonaconta- 12 dodeca- 100 hecta- 13 trideca- 200 dicta- 14 tetradeca- 300 tricta- 15 pentadeca-
The tert-butyloxycarbonyl group is marked blue. Amines have a special importance in peptide synthesis, but are a quite potent nucleophile and also relatively strong bases. These characteristics imply that new protecting groups for amines are always under development. [47] Amine groups are primarily protected through acylation, typically as a ...
The effect of the tert-butyl group on the progress of a chemical reaction is called the Thorpe–Ingold effect illustrated in the Diels-Alder reaction below. Compared to a hydrogen substituent, the tert-butyl substituent accelerates the reaction rate by a factor of 240. [2] tert-Butyl effect. The tert-butyl effect is an example of steric hindrance.
Mono-BOC-cystamine (mono BOC protected cystamine) is a tert-butyloxycarbonyl (BOC) derivative of cystamine used as crosslinker in biotechnology and molecular biology applications. [1] This compound was originally reported by Hansen et al .
Bis(2,4-di-tert-butylphenyl) pentaerythritol diphosphite is an organophosphite used as a polymer stabilizer in plastics. Like other phosphite antioxidants it primarily acts to remove hydroperoxides and is typically used in combination with hindered phenolic antioxidants such as pentaerythritol tetrakis(3,5-di-tert-butyl-4-hydroxyhydrocinnamate) .
Di-tert-butyl-iminodicarboxylate is an organic compound that can be described with the formula [(CH 3) 3 COC(O)] 2 NH. It is a white solid that is soluble in organic solvents. The compound is used as a reagent for the preparation of primary amines from alkyl halides. [1] It was popularized as an alternative to the Gabriel synthesis for the same ...