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Varenicline, sold under the brand names Chantix and Champix among others, is a medication used for smoking cessation [5] [7] and for the treatment of dry eye syndrome. [ 6 ] [ 8 ] It is a nicotinic acetylcholine receptor partial agonist .
The nAChRs take part in the depolarization of the muscular endplate by increasing cation permeability leading to contraction of skeletal muscles. [16] The nAChRs found in the skeletal muscle system have two ACh binding sites, one of which is found at the interface between α1 and δ subunits while the other one is found at the interface between ...
On July 1, 2009, the FDA required Chantix (varenicline) to carry a boxed warning due to public reports of side effects including depression, suicidal thoughts, and suicidal actions. As of 2016 [update] , the warning has been removed on the basis of updated evidence.
CHANTIX ® (varenicline) Demonstrates Efficacy in Smokers Who Previously Attempted to Quit Smoking with CHANTIX New Positive Top-line Results in Adult Smokers Re-treated With CHANTIX NEW YORK ...
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In other words, out of 100 people who will take medication, approximately 8 of them would remain non-smoking after one year thanks to the treatment. [22] During one year, the benefit from using smoking cessation medications (Bupropion, NRT, or varenicline) decreases from 17% in 3 months, to 12% in 6 months to 8% in 12 months. [22]
A 2013 meta-analysis of eight studies demonstrated that cytisine has similar effectiveness to varenicline but with substantially lower side effects. [13] A 2014 systematic review and economic evaluation concluded that cytisine was more likely to be cost-effective for smoking cessation than varenicline. [14]
(Photo Credit: Jose Perez/Bauer-Griffin / Contributor | GC Images via Getty Images)
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109 S High St #100, Columbus, OH · Directions · (614) 224-4261