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A third important effect of PTH on the kidneys is stimulation of the conversion of 25-hydroxy vitamin D into 1,25-dihydroxy vitamin D (calcitriol). [216] This form of vitamin D is the active hormone which promotes calcium uptake from the intestine via the action of calbindin. [218] Calcitriol also reduces calcium loss to urine. [215]
The Institute of Medicine in 2010 recommended a maximum uptake of vitamin D of 4000 IU/d, finding that the dose for lowest observed adverse effect level is 40,000 IU daily for at least 12 weeks, [25] and that there was a single case of toxicity above 10 000 IU after more than seven years of daily intake; this case of toxicity occurred in ...
The melt is made up of various components of pre-existing rocks which have been subjected to melting either at subduction zones or within the Earth's mantle. The melt is hot and so passes upward through cooler country rock. As it moves, it cools and various rock types will form through a process known as fractional crystallisation.
Slate – Metamorphic rock - A low grade metamorphic rock formed from shale or silt; Suevite – Rock consisting partly of melted material formed during an impact event – A rock formed by partial melting during a meteorite impact; Talc carbonate – A metamorphosed ultramafic rock with talc as an essential constituent; similar to a serpentinite
Metamorphic rocks are formed by subjecting any rock type—sedimentary rock, igneous rock or another older metamorphic rock—to different temperature and pressure conditions than those in which the original rock was formed. This process is called metamorphism, meaning to "change in form". The result is a profound change in physical properties ...
Calcifediol is the precursor for calcitriol, the active form of vitamin D. [3] [4] It is synthesized in the liver, by hydroxylation of cholecalciferol (vitamin D 3) at the 25-position. [3] This enzymatic 25-hydroxylase reaction is mostly due to the actions of CYP2R1 , present in microsomes , although other enzymes such as mitochondrial CYP27A1 ...
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