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Diabetic cats do best with long-lasting twice-daily injections of insulin such as glargine (which as of 2022 is available worldwide as a synthetic generic drug) combined with a low carbohydrate diet. Because diabetes is a disease of carbohydrate metabolism, a move to a primarily protein and fat diet reduces the occurrence and recurrence of ...
Velagliflozin, sold under the brand name Senvelgo, is an antidiabetic medication used for the treatment of cats. [2] [4] Velagliflozin is a sodium-glucose cotransporter 2 (SGLT2) inhibitor. [5] It is taken by mouth. [2]
Insulin resistance can vary greatly between cats. In some cases glycaemic control can be achieved with doses of 1 to 3 U/cat b.i.d., a 'normal' level of insulin dosage. Insulin levels should be increased by 0.5 to 1 U/cat b.i.d. every 5 to 7 days until glycaemic control has been achieved (blood glucose level of 100 to 300 mg/dL).
There are e.g. advocates that Glargine should always be used to hold the blood sugar concentration in the physiological range (50-100mg/dL) and not above 100mg/dL as suggested in the article. The reason for this is quite clear, it's actually much harder - according to some studies - to hold the daily range between 100-180 than in the normal ...
Insulin glargine differs from human insulin by replacing asparagine with glycine in position 21 of the A-chain and by carboxy-terminal extension of B-chain by 2 arginine residues. The arginine amino acids shift the isoelectric point from a pH of 5.4 to 6.7, making the molecule more soluble at an acidic pH and less soluble at physiological pH.
Insulin was first used as a medication in Canada by Charles Best and Frederick Banting in 1922. [85] [86] This is a chronology of key milestones in the history of the medical use of insulin. For more details on the discovery, extraction, purification, clinical use, and synthesis of insulin, see Insulin
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