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The pancreatic islets or islets of Langerhans are the regions of the pancreas that contain its endocrine (hormone-producing) cells, discovered in 1869 by German pathological anatomist Paul Langerhans. [1] The pancreatic islets constitute 1–2% of the pancreas volume and receive 10–15% of its blood flow. [2] [3] The pancreatic islets are ...
Beta cells (β-cells) are specialized endocrine cells located within the pancreatic islets of Langerhans responsible for the production and release of insulin and amylin. [1] Constituting ~50–70% of cells in human islets, beta cells play a vital role in maintaining blood glucose levels. [2] Problems with beta cells can lead to disorders such ...
The tissues with an endocrine role within the pancreas exist as clusters of cells called pancreatic islets (also called islets of Langerhans) that are distributed throughout the pancreas. [9] Pancreatic islets contain alpha cells, beta cells, and delta cells, each of which releases a different hormone.
At first, there was a lot of controversy about what the Islets were made of and what they did. [3] It appeared that all of the cells were the same within the Islet, but were histologically distinct from acini cells. [3] Laguesse discovered that the cells within the Islets of Langerhans contained granules that distinguished them from acini cells ...
In adult pancreas samples, they are observed to be round or oval shaped and remain localized on the mantle of the islets in different amounts, both in clusters and or single cells. In mice, ε-cells are present in the pancreatic islets and stomach during development, but are found strictly in the stomach after birth.
Pancreatic polypeptide cells (PP cells), or formerly as gamma cells (γ-cells), or F cells, are cells in the pancreatic islets (Islets of Langerhans) of the pancreas. Their main role is to help synthesize and regulate the release of pancreatic polypeptide (PP) , after which they have been named.
Paul Langerhans (25 July 1847 – 20 July 1888) was a German pathologist, physiologist and biologist, credited with the discovery of the cells that secrete insulin, named after him as the islets of Langerhans.
Exocrine component of pancreas Pancreatic ductal cells; Pancreatic acinar cell; Centroacinar cell; Pancreatic stellate cell; Islets of Langerhans. Alpha cell; Beta cell; PP cell (F cell, gamma cell) Delta cell; Epsilon cell