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The mixture was reportedly first developed by Rahmat Sulistyo in 1930, as a family recipe. It was first sold to the public at Yogyakarta in 1940 as a premixed jamu, though due to the Indonesian National Revolution the family moved to Semarang and there in 1951 the company Sido Muncul was founded.
Mithradates the VI, reputed for intentionally consuming poison to build immunity. Mithridatism is the practice of protecting oneself against a poison by gradually self-administering non-lethal amounts.