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Porphobilinogen (PBG) is an organic compound that occurs in living organisms as an intermediate in the biosynthesis of porphyrins, which include critical substances like hemoglobin and chlorophyll. [ 1 ]
The lytic cycle is often separated into six stages: attachment, penetration, transcription, biosynthesis, maturation, and lysis. Attachment – the phage attaches itself to the surface of the host cell in order to inject its DNA into the cell; Penetration – the phage injects its DNA into the host cell by penetrating through the cell membrane
It catalyzes the following reaction, the second step of the biosynthesis of porphyrin: 2 5-Aminolevulinic acid porphobilinogen + 2 H 2 O. It therefore catalyzes the condensation of 2 molecules of 5-aminolevulinate to form porphobilinogen (a precursor of heme, cytochromes and other hemoproteins). This reaction is the first common step in the ...
The most well-known health issue involving porphobilinogen deaminase is acute intermittent porphyria, an autosomal dominant genetic disorder where insufficient hydroxymethylbilane is produced, leading to a build-up of porphobilinogen in the cytoplasm. This is caused by a gene mutation that, in 90% of cases, causes decreased amounts of enzyme.
The prokaryotic cell is shown with its DNA, in green. 2. The bacteriophage attaches and releases its DNA, shown in red, into the prokaryotic cell. 3. The phage DNA then moves through the cell to the host's DNA. 4. The phage DNA integrates itself into the host cell's DNA, creating prophage. 5. The prophage then remains dormant until the host ...
Despite the wide range of organisms that synthesize protoporphyrin IX, the process is largely conserved from bacteria to mammals with a few distinct exceptions in higher plants. [ 12 ] [ 13 ] [ 14 ] In the biosynthesis of those molecules, the metal cation is inserted into protoporphyrin IX by enzymes called chelatases .
The lack of 32 P-labeled DNA remaining in the solution after the bacteriophages had been allowed to adsorb to the bacteria showed that the phage DNA was transferred into the bacterial cell. The presence of almost all the radioactive 35 S in the solution showed that the protein coat that protects the DNA before adsorption stayed outside the cell ...
Bacteriophage Qbeta (Qubevirus durum), commonly referred to as Qbeta or Qβ, is a species consisting of several strains of positive-strand RNA virus which infects bacteria that have F-pili, most commonly Escherichia coli. Its linear genome is packaged into an icosahedral capsid with a diameter of 28 nm. [1]