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Dorzolamide, sold under the brand name Trusopt among others, is a medication used to treat high pressure inside the eye, including in cases of glaucoma. [3] It is used as an eye drop. [3] Effects begin within three hours and last for at least eight hours. [3] It is also available as the combination dorzolamide/timolol. [3] [4]
Dorzolamide/timolol, sold under the brand name Cosopt among others, is a medication used to treat high pressure inside the eye including glaucoma. [3] [5] [6] It is a combination of dorzolamide hydrochloride and timolol maleate. [3] It may be used when a beta blocker, like timolol, is not sufficient alone. [7] It is used as an eye drop. [3]
Timolol is available as a generic medication. [ 3 ] [ 9 ] In 2022, it was the 155th most commonly prescribed medication in the United States, with more than 3 million prescriptions. [ 10 ] [ 11 ]
Doris Taylor MBE founded Meals on Wheels in South Australia in 1953, and in 1954 the first meal was served from the Port Adelaide kitchen. [9] In New South Wales, Meals on Wheels was started in March 1957 by the Sydney City Council. In the first week, 150 meals were served for inner city dwellers; these were cooked in the Town Hall kitchen. [4]
Food scraps: moldy food, leftovers, rotting food Green waste: branches, grass, leaves, tree trimmings, prunings Here’s what shouldn’t go into the bin, according to the website:
Photograph by Edward S. Curtis U.S. Federal Emergency Management Agency (FEMA) food storage containers stacked on shipping pallets in Texas, 2008. A new braided granary is inaugurated. Kapsiki, North Cameroon. Food storage is a way of decreasing the variability of the food supply in the face of natural, inevitable variability. [1]
Meals on Wheels of America is a national organization of community-based senior nutrition programs providing over one million meals each day. [3] According to the website, the vision of Meals on Wheels of America is to see no senior go hungry by providing meals to seniors at a fraction of the cost of living in a senior facility. [1]
While definitive sites of metabolism have not been firmly established, there are several metabolites worthy of note. N-Desethylbrinzolamide is an active metabolite of the parent compound, and thus exhibits carbonic anhydrase inhibitory activity (largely carbonic anhydrase-I, when in the presence of Brinzolamide) and also accumulates in the erythrocytes.