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For patients with more than 1,000 PVCs per day, the risk of developing left ventricular systolic dysfunction after 5 years follow-up is low. Frequent PVCs may increase the risk of developing cardiomyopathy, which can greatly impair heart function. A PVC burden greater than 10% is the minimal threshold for development of PVC-induced cardiomyopathy.
The second Cardiac Arrhythmia Suppression Trial (CAST II) modified the enrollment criteria to include patients at higher risk for serious arrhythmia. [4] This included 1) patients enrolled within 4 to 90 days of a previous MI, 2) a left ventricular ejection fraction lower than 40%, 3) prior to enrollment, suppression of PVCs had occurred with the drugs (vs. placebo) using a double-blinded ...
Flecainide is a medication used to prevent and treat abnormally fast heart rates. [1] This includes ventricular and supraventricular tachycardias . [ 1 ] Its use is only recommended in those with dangerous arrhythmias or when significant symptoms cannot be managed with other treatments. [ 1 ]
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Accessory pathways may not require any treatment, but those causing symptoms may be treated with medication including calcium channel antagonists, beta blockers or flecainide. [3] Alternatively, the electrical conduction through an accessory pathways can be abolished using catheter ablation, potentially offering a permanent cure. [3]
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PVCs that occur at intervals of 2 normal beats to 1 PVC, or 1 normal beat to 2 PVCs, are termed "PVCs in trigeminy" [13] Groups of three premature ventricular beats are called triplets and are considered a brief run of non-sustained ventricular tachycardia (NSVT); if the grouping lasts for more than 30 seconds, it is considered sustained ...
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