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Cannabidiol can be taken internally in multiple ways, including by inhaling cannabis smoke or vapor, oral, and as an aerosol spray into the cheek. [4] [5] It may be supplied as CBD oil containing only CBD as the active ingredient (excluding THC or terpenes), CBD-dominant hemp extract oil, capsules, dried cannabis, or prescription liquid solution.
Hash oil can be the most potent of the main cannabis products because of its high level of psychoactive compound per its volume, which can vary depending on the plant's mix of essential oils and psychoactive compounds. [181] Butane and supercritical carbon dioxide hash oil have become popular in recent years. [182]
CBD is hydroxylated by P450 liver enzymes into 7-OH-CBD. Its metabolites are products of primarily CYP2C19 and CYP3A4 activity, with potential activity of CYP1A1, CYP1A2, CYP2C9, and CYP2D6. [69] Similar to delta-9-THC, a majority of CBD is excreted in feces and some in the urine. [57] The terminal half-life is approximately 18–32 hours. [70]
CBD shares a precursor with THC and is the main cannabinoid in CBD-dominant Cannabis strains. CBD has been shown to play a role in preventing the short-term memory loss associated with THC. [29] There is tentative evidence that CBD has an anti-psychotic effect, but research in this area is limited. [30] [24]
Female cannabis plants contain at least 113 cannabinoids, [54] including cannabidiol (CBD), thought to be the major anticonvulsant that helps people with multiple sclerosis, [55] and cannabichromene (CBC), an anti-inflammatory which may contribute to the pain-killing effect of cannabis.
Synthetic cannabinoids reagent testing kits have recently become economical. It is often difficult to determine what is in these products without reagent testing because masking agents, such as tocopherol (or vitamin E acetate that causes vaping-associated pulmonary injury), eugenol, and fatty acids, are added to confound identification.