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In people who lose weight as a side effect of Wellbutrin, it is possible to notice weight changes within eight weeks. However, Wellbutrin is not a weight-loss drug and may not produce consistent results when taken for this purpose.
Weight changes are considered a side effect for both Wellbutrin XL and Wellbutrin SR. Studies of Wellbutrin XL show that 23% of people taking a dose of 150 to 300 mg per day lost 5 pounds or more. In the same studies, 11% of people gained more than 5 pounds.
In the drug’s studies, participants experienced both weight gain and weight loss, but weight loss was more common. Changes in weight can also be a symptom of depression .
Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.
Very common (10% or more): Weight loss greater than 2.3 kg (up to 28%), weight gain greater than 2.3 kg (up to 11%) Common (1% to 10%): Anorexia, decreased appetite, increased appetite, thirst/thirst disturbance
Get medical help right away if you have any very serious side effects, including: eye pain/swelling/redness, widened pupils, vision changes (such as seeing rainbows around lights at night),...
In the continuation phase, 14 bupropion responders who completed 24 weeks achieved weight loss of 12.9% +/- 5.6% with fat accounting for 73.5% +/- 3.7% of the weight lost and no change in bone mineral density as assessed by DXA. Bupropion was generally well-tolerated in this sample.