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Diltiazem, sold under the brand name Cardizem among others, is a nondihydropyridine calcium channel blocker medication used to treat high blood pressure, angina, and certain heart arrhythmias. [9] It may also be used in hyperthyroidism if beta blockers cannot be used. [ 9 ]
In the kidneys, dofetilide is eliminated via cation exchange (secretion). Agents that interfere with the renal cation exchange system, such as verapamil , cimetidine , hydrochlorothiazide , itraconazole , ketoconazole , prochlorperazine , and trimethoprim should not be administered to individuals taking dofetilide.
Nephrotoxicity is toxicity in the kidneys. It is a poisonous effect of some substances, both toxic chemicals and medications, on kidney function. [1] There are various forms, [2] and some drugs may affect kidney function in more than one way. Nephrotoxins are substances displaying nephrotoxicity.
Prolonged high blood pressure, or hypertension, can lead to severe complications such as heart disease, stroke, kidney failure and vision loss. Yet millions of Americans are living with elevated ...
“SGLT2 inhibitors’ direct effects on the kidneys relate to blood pressure reduction, which has cardioprotective effects, especially in heart failure — increasing the efficiency of heart ...
A new study suggests that people with chronic kidney disease, type 2 diabetes, or both of these conditions may face an elevated cardiovascular disease (CVD) risk 8 to 28 years earlier than those ...
Triamterene directly blocks the epithelial sodium channel [4] (ENaC) on the lumen side of the kidney collecting tubule. [5]: 127 Other diuretics cause a decrease in the sodium concentration of the forming urine due to the entry of sodium into the cell via the ENaC, and the concomitant exit of potassium from the principal cell into the forming urine.
Loop diuretics may also precipitate kidney failure in patients concurrently taking an NSAID and an ACE inhibitor—the so-called "triple whammy" effect. [19] Because furosemide, torsemide and bumetanide are technically sulfa drugs, there is a theoretical risk that patients sensitive to sulfonamides may be sensitive to these loop diuretics. This ...
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