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The conditions described here are separate from the HSAN group of disorders, which have more specific signs and cause. Because feeling physical pain is vital for survival, CIP is an extremely dangerous condition. [1] It is common for people with the condition to die in childhood due to injuries or illnesses going unnoticed.
Since people with this condition are unable to sweat, they are unable to properly regulate their body temperature. [1] Those affected are unable to feel pain and temperature. [2] [3] The absence of pain experienced by people with CIPA puts them at high risk for accidental self-injury. Corneal ulceration occurs due to lack of protective impulses ...
' pain receptor ') is a sensory neuron that responds to damaging or potentially damaging stimuli by sending "possible threat" signals [1] [2] [3] to the spinal cord and the brain. The brain creates the sensation of pain to direct attention to the body part, so the threat can be mitigated; this process is called nociception.
Afferent pain-receptive nerves, those that bring signals to the brain, comprise at least two kinds of fibers - a fast, relatively thick, myelinated "Aδ" fiber that carries messages quickly with intense pain, and a small, unmyelinated, slow "C" fiber that carries the longer-term throbbing and chronic pain. Large-diameter Aβ fibers are ...
Injuries such as osseous fractures, skin burns, bruises and more serious ailments such as internal bleeding and appendicitis have a higher occurrence rate among people with the condition, since they don't have a concept of pain, they don't have a way of knowing if they have been injured or if they are suffering from pain in an area of their body that isn't the head or the stomach.
Nociceptive pain consists of an adaptive alarm system. [6] Nociceptors have a certain threshold; that is, they require a minimum intensity of stimulation before they trigger a signal. Once this threshold is reached, a signal is passed along the axon of the neuron into the spinal cord.
Opioids refers to a specific group of analgesics – including morphine, codeine, and opium – that act on opioid receptors, which are located mainly in the central nervous system. [citation needed] Endogenous opioids are types of opioids produced by the body specifically to modulate pain.
Nociplastic pain is a longterm complex pain, one of three mechanisms of pain, defined by the International Association for the Study of Pain as "pain that arises from altered nociception despite no clear evidence of actual or threatened tissue damage causing the activation of peripheral nociceptors or evidence for disease or lesion of the somatosensory system causing the pain". [2]