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Katalin "Kati" Karikó (Hungarian: Karikó Katalin, pronounced [ˈkɒrikoː ˌkɒtɒlin]; born 17 January 1955) is a Hungarian-American [2] biochemist who specializes in ribonucleic acid ()-mediated mechanisms, particularly in vitro-transcribed messenger RNA (mRNA) for protein replacement therapy. [3]
Entry of mRNA molecules, however, faces a number of difficulties. Not only are mRNA molecules too large to cross the cell membrane by simple diffusion, they are also negatively charged like the cell membrane, which causes a mutual electrostatic repulsion. Additionally, mRNA is easily degraded by RNAases in skin and blood. [55]
Drew Weissman (born September 7, 1959) is an American physician and immunologist known for his contributions to RNA biology. Weissman is the inaugural Roberts Family Professor in Vaccine Research, director of the Penn Institute for RNA Innovation, and professor of medicine at the Perelman School of Medicine at the University of Pennsylvania (Penn).
Here are five things to know about Karikó and Weissman’s game-changing research and mRNA vaccines. What mRNA does Messenger RNA, or mRNA, is a form of nucleic acid that tells cells what to do ...
The bird flu outbreak in U.S. dairy cows is prompting development of new, next-generation mRNA vaccines — akin to COVID-19 shots — that are being tested in both animals and people. Next month ...
The skin was made in a lab at the University of Tokyo from a mixture of human skin cells grown on a collagen model and placed on top of a 3D-printed resin base, the New Scientist reported.
Unusual names have caused issues for scientists explaining genetic diseases to lay-people, such as when an individual is affected by a gene with an offensive or insensitive name. [13] This has particularly been noted in patients with a defect in the sonic hedgehog gene pathway and the disease formerly named CATCH22 for "cardiac anomaly, T-cell ...
In 2007, Moore moved her research group to the Biochemistry and Molecular Pharmacology Department at the University of Massachusetts Chan Medical School (UMass Med). [ 9 ] [ 10 ] In 2011, Moore was the recipient of the American Society for Biochemistry and Molecular Biology 's William C. Rose Award [ 11 ] for excellence in mentoring.