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In men with prostate cancer, the ratio of free (unbound) PSA to total PSA is decreased. The risk of cancer increases if the free to total ratio is less than 25%. (See graph) The lower the ratio is, the greater the probability of prostate cancer. Measuring the ratio of free to total PSA appears to be particularly promising for eliminating ...
The 4Kscore combines total, free and intact PSA together with human kallikrein 2. [46] It is used to try to determine the risk of a Gleason score greater than 6. [46] The Prostate Health Index (PHI) is a PSA-based blood test for early prostate cancer screening. It may be used to determine when a biopsy is needed.
Those with elevated PSA may undergo secondary screening blood tests that measure subtypes of PSA and other molecules to better predict the likelihood that a person will develop aggressive prostate cancer. Many measure "free PSA" – the fraction of PSA unbound to other blood proteins, usually around 10% to 30%.
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56318 Ensembl ENSG00000014257 ENSMUSG00000032561 UniProt P15309 Q8CE08 RefSeq (mRNA) NM_001099 NM_001134194 NM_001292037 NM_019807 NM_207668 RefSeq (protein) NP_001090 NP_001127666 NP_001278966 NP_062781 NP_997551 Location (UCSC) Chr 3: 132.32 – 132.37 Mb Chr 9: 104.17 – 104.21 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Prostatic acid phosphatase (PAP), also prostatic ...
Richard J. Ablin (May 15, 1940 – October 6, 2023) [1] was an American scientist, most notable for research on prostate cancer.According to the Wall Street Journal: . Richard Ablin, a professor of pathology at University of Arizona College of Medicine, discovered the prostate-specific antigen (PSA) in 1970, and for nearly as long, he has argued that it should not be used for routine screening.
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