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Injectable filler is a special type of substance made for injections into connective tissues, such as skin, cartilage or even bone, for cosmetic or medical purposes.The most common application of injectable fillers is to change one's facial appearance, but they also are used to reduce symptoms of osteoarthritis, treat tendon or ligament injuries, support bone and gum regeneration, and for ...
Restylane is the trade name for a range of injectable fillers with a specific formulation of hyaluronic acid (HA). In the United States, Restylane was the first hyaluronic acid filler to be approved by the U.S. Food and Drug Administration (FDA) for cosmetic injection into subdermal facial tissues. [1] Restylane is produced by Galderma.
In osteoarthritis, joint injection of glucocorticoids (such as hydrocortisone) leads to short term pain relief that may last between a few weeks and a few months. [5] Injections of hyaluronic acid have not produced improvement compared to placebo for knee arthritis, [6] [7] but did increase risk of further pain. [6]
Hyaluronic acid (Juvederm, Restylane, Perlane or Voluma) – low hypoallergenic temporary filler that lasts for 6 to 10 months. This filler can be dissolved with injections of an enzyme called hyaluronidase. [7] [8] Liquid silicone – Medical grade silicone is sometimes used in a microdroplet technique for permanent versions of the procedure.
Hyaluronic acid is a polymer of disaccharides, which are composed of D-glucuronic acid and N-acetyl-D-glucosamine, linked via alternating β-(1→4) and β-(1→3) glycosidic bonds. Hyaluronic acid can be 25,000 disaccharide repeats in length. Polymers of hyaluronic acid can range in size from 5,000 to 20,000,000 Da in vivo.
Restylane, a non-animal, clear gel that is reported to be very close to the hyaluronic acid found naturally in the body. According to the American Society of Plastic Surgeons, there were 778,000 cases of Restylane injection in 2006, the most recent year for which statistics are available. The substance usually lasts six months and, sometimes ...
The resulting hyaluronic acid fragments of variable size are then further hydrolyzed by HYAL1 after being internalized into endo-lysosomes; this generates hyaluronic acid oligosaccharides. [ 5 ] Hyaluronidases are hyaluronoglucosidases ( EC 3.2.1.35 ), i.e. they cleave the (1→4)-linkages between N-acetylglucosamine and glucuronate.
In October 2020, Hims closed a deal with Oaktree Capital Management to go public through a blank check company, reaching a valuation of $1.6 billion. [7] As part of the deal, the company was renamed Hims & Hers Health Inc. [11] The transaction was completed in January 2021, and the company started trading publicly on the New York Stock Exchange.
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