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Peak-to-trough ratio in pharmacokinetics is the ratio of peak (C max) and trough (C min) levels of a drug over its dosing interval (τ) at steady state.. Peak-to-trough ratio (PTR), also known as peak-to-trough variation or peak-to-trough fluctuation, is a parameter in pharmacokinetics which is defined as the ratio of C max (peak) concentration and C min (trough) concentration over a dosing ...
In a medicine that is administered periodically, the trough level should be measured just before the administration of the next dose in order to avoid overdosing. [3] A trough level is contrasted with a "peak level" (C max), which is the highest level of the medicine in the body, and the "average level", which is the mean level over time. It is ...
At a practical level, a drug's bioavailability can be defined as the proportion of the drug that reaches the systemic circulation. From this perspective the intravenous administration of a drug provides the greatest possible bioavailability, and this method is considered to yield a bioavailability of 1 (or 100%).
The variation can be described as a periodic function, which in turn can be split into a DC component (the peak value) [a] and an AC component (peak minus trough). [42] The ratio of the AC component to the DC component, expressed as a percentage, is known as the (peripheral) perfusion index (Pi) for a pulse, and typically has a range of 0.02% ...
A trough is an elongated area of lower air pressure. Since pressure is closely linked to wind, there are often changes in wind direction across a trough. If a trough forms in the mid-latitudes, a temperature difference at some distance between the two sides of the trough usually exists and the trough might become a weather front at some
The peak expiratory flow (PEF), also called peak expiratory flow rate (PEFR) and peak flow measurement, [1] is a person's maximum speed of expiration, as measured with a peak flow meter, a small, hand-held device used to monitor a person's ability to breathe out air.
Observe the two bands shown girdling the stream—one at a peak and the other at a trough of the wave. At the trough, the radius of the stream is smaller, hence according to the Young–Laplace equation the pressure due to surface tension is increased. Likewise at the peak the radius of the stream is greater and, by the same reasoning, pressure ...
Calorimetry may be used to monitor the course of a reaction, since the instantaneous heat flux of the reaction, which is directly related to the enthalpy change for the reaction, is monitored. Reaction calorimetry may be classified as a differential technique since the primary data collected are proportional to rate vs. time.