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NAD-dependent deacetylase sirtuin-3, mitochondrial also known as SIRT3 is a protein that in humans is encoded by the SIRT3 gene [sirtuin (silent mating type information regulation 2 homolog) 3 (S. cerevisiae)]. [5] [6] SIRT3 is member of the mammalian sirtuin family of proteins, which are homologs to the yeast Sir2 protein.
It was the first-discovered member of the Sirtuin protein family and it is highly conserved, with homologs found in organisms ranging from humans to bacteria [16] and archaea. [12] It interacts with a variety of protein substrates, but does not exhibit strong affinity for DNA, chromatin, or other silencer-binding factors. [ 12 ]
Unlike other known protein deacetylases, which simply hydrolyze acetyl-lysine residues, the sirtuin-mediated deacetylation reaction couples lysine deacetylation to NAD+ hydrolysis. [12] This hydrolysis yields O-acetyl-ADP-ribose, the deacetylated substrate and nicotinamide, which is an inhibitor of sirtuin activity itself.
The US government recommends people eat 0.36 g of protein per pound of body weight, or at least 46 grams for women and 56g for men. For building lean muscle mass, research suggests 0.7 grams per ...
A peptide microarray (also commonly known as peptide chip or peptide epitope microarray) is a collection of peptides displayed on a solid surface, usually a glass or plastic chip. Peptide chips are used by scientists in biology, medicine and pharmacology to study binding properties and functionality and kinetics of protein-protein interactions ...
The company also offers a wide variety of other high-protein items, including protein powder, protein shakes, and high-protein cookies, chips, crackers, candy, frozen pizza, and pasta. [3] [8] [9] Quest's protein bars derive their protein from whey protein isolate and milk protein isolate. [8]
The highest concentrations of heavy metals were found in organic, plant-based, and these types of protein powders. Some protein powders contain cancer-causing toxins, new study shows, and these 3 ...
Sirtuin-activating compounds (STAC) are chemical compounds having an effect on sirtuins, a group of enzymes that use NAD+ to remove acetyl groups from proteins. They are caloric restriction mimetic compounds that may be helpful in treating various aging -related diseases.
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