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Studies of Finnish mothers who were pregnant when they learned their husbands were killed during the Winter War of 1939–1940 had children who were significantly more likely to develop schizophrenia when compared with mothers who learned about their husbands' deaths after childbirth, suggesting that prenatal stress may have an effect as well. [55]
Schizophrenia is a debilitating and often misunderstood disorder that affects up to 1% of the world's population. [1] Although schizophrenia is a heavily studied disorder, it has remained largely impervious to scientific understanding; epigenetics offers a new avenue for research, understanding, and treatment.
"First degree relatives" are found to have the highest chance of being diagnosed with schizophrenia. Children of individuals with schizophrenia have a 8.2% chance of having schizophrenia while the general population is at an 0.86% chance of having this disorder. [28] These results indicate that genes play a big role in one developing schizophrenia.
The causes of schizophrenia that underlie the development of schizophrenia, a psychiatric disorder, are complex and not clearly understood.A number of hypotheses including the dopamine hypothesis, and the glutamate hypothesis have been put forward in an attempt to explain the link between altered brain function and the symptoms and development of schizophrenia.
Several models have been put forward to explain the link between altered brain function and schizophrenia. [27] The prevailing model of schizophrenia is that of a neurodevelopmental disorder, and the underlying changes that occur before symptoms become evident are seen as arising from the interaction between genes and the environment. [126]
Other diseases and infections in mothers whom are pregnant have been linked to increased risk of schizophrenia. These include, mothers who have the herpes simplex virus, meningitis, and even celiac disease. In a Danish study, children whose mothers have celiac disease were two times more likely to develop schizophrenia later in life. [23]
Iris and Hester were both circumcised as children in order to prevent them from masturbation. [3] [2] The quadruplets were reportedly physically abused by their father, given the pseudonym Mr. Genain. Subsequently, the Genains accepted an offer by the NIMH to take the daughters into their clinic and each was diagnosed with schizophrenia.
The other hypothesis, which has an unknown cause, is the capacity to think in minimal-educated families where the children in these families are more likely to have schizophrenic reactions. [ 3 ] In their book, Schizophrenia and the Family (1965), Lidz, Fleck and Alice Cornelison compiled findings of what remains perhaps the most detailed ...
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