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1–40 years Head and hand tremor 8q SCA17 CAG repeat, 6q (TATA-binding protein) SCA19, SCA22 (KCND3 [24]) Mild cerebellar syndrome, dysarthria SCA25: 1.5–39 yrs Unknown ataxia with sensory neuropathy, vomiting and gastrointestinal pain. 2p SCA27 [25] (FGF14 [24]) 15–20 yrs Unknown ataxia with poor cognition, dyskinesias and tremor.
The study included 589 people, with an average age of 40 at the start. Participants completed sleep questionnaires at the beginning of the study and then again five years later. Researchers ...
Spinal and bulbar muscular atrophy (SBMA), popularly known as Kennedy's disease, is a rare, adult-onset, X-linked recessive lower motor neuron disease caused by trinucleotide CAG repeat expansions in exon 1 of the androgen receptor (AR) gene, which results in both loss of AR function and toxic gain of function.
A spinal CSF leak can be caused by one or more meningeal diverticula or CSF-venous fistulas not associated with an epidural leak. [6] [7] [8] A spontaneous spinal cerebrospinal fluid leak may occur sometimes in those with predisposing heritable connective tissue disorders including Marfan syndrome and Ehlers–Danlos syndromes.
In the more narrow sense, it refers to spinal osteoarthritis, the age-related degeneration of the spinal column, which is the most common cause of spondylosis. The degenerative process in osteoarthritis chiefly affects the vertebral bodies, the neural foramina and the facet joints ( facet syndrome ).
Overall, this degeneration leads to clinical parkinsonism. Historically, starting in 1917 an epidemic of encephalitis lethargica , also called von Economo's encephalitis or "sleepy-disease" occurred, possibly related to the 1918 Spanish flu pandemic; however, even with the use of modern molecular diagnostic tests on appropriate corpses, no firm ...
nystagmus (rapid, involuntary eye movements), causing sleep disturbances; ophthalmoplegia (paralysis of extraocular muscles) diplopia (double vision) Scientific studies have revealed that psychiatric symptoms are also common in patients with cerebellar degeneration, [5] [6] where dementia is a typical psychiatric disorder resulting from ...
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