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Leflunomide, sold under the brand name Arava among others, is an immunosuppressive disease-modifying antirheumatic drug , [8] used in active moderate-to-severe rheumatoid arthritis and psoriatic arthritis. It is a pyrimidine synthesis inhibitor that works by inhibiting dihydroorotate dehydrogenase. [9] Bottle of Leflunomide (Arava) and tablet
In order for a T cell to be activated and produce an immune response, an antigen-presenting cell must present two signals to the T cell. One of those signals is the major histocompatibility complex (MHC), combined with the antigen, and the other signal is the CD80 or CD86 molecule (also known as B7-1 and B7-2).
Auranofin is used to treat rheumatoid arthritis.It improves arthritis symptoms including painful or tender and swollen joints and morning stiffness. [5] Auranofin is a safer treatment compared to the more common injectable gold thiolates (gold sodium thiomalate and gold thioglucose), but meta-analysis of 66 clinical trials concluded that it is somewhat less effective.
Essential fatty acids, such as omega 3s, are key to the strength and performance of the brain’s cells. Since the human body can’t produce essential fatty acids on its own, they must come from ...
Sentinel cells refer to cells in the body's first line of defense, which embed themselves in tissues such as skin. [1] Sentinel cells represent diverse array of cell types with the capability to monitor the presence of exogenous or potentially harmful particles and play a crucial role in recognizing and sampling signs of infection or abnormal cellular activity and/or death.
In contrast, many other cell types use both pathways, and some cells, such as terminally differentiated neurons, depend completely on purine nucleotide salvage. [36] Thus, use of mycophenolic acid leads to a relatively selective inhibition of DNA replication in T cells and B cells .
Alefacept is a genetically engineered immunosuppressive drug.It was sold under the brand name Amevive in Canada, the United States, Israel, Switzerland and Australia.In 2011, the manufacturers made a decision to cease promotion, manufacturing, distribution and sales of Amevive during a supply disruption.
Beyond our T cell engagers, Bemarituzumab, our first-in-class fibroblast growth factor receptor 2b-directed monoclonal antibody, is advancing to frontline gastric cancer therapy.